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1

Evaluation of chemopreventive agents for genotoxic activity

Rupa S. Doppalapudi, Edward S. Riccio, Linda L. Rausch, Julie A. Shimon, Pam S. Lee, Kristien E. Mortelmans, Izet M. Kapetanovic, James A. Crowell, Jon C. Mirsalis

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 308 KB

english, 2007

2

Toxicity of dolastatin 10 in mice, rats and dogs and its clinical relevance

Jon C. Mirsalis, Janice Schindler-Horvat, James R. Hill, Joseph E. Tomaszewski, Susan J. Donohue, Charles A. Tyson

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 128 KB

english, 1999

3

Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection

Ekins, Sean, Lingerfelt, Mary A., Comer, Jason E., Freiberg, Alexander N., Mirsalis, Jon C., O'Loughlin, Kathleen, Harutyunyan, Anush, McFarlane, Claire, Green, Carol E., Madrid, Peter B.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2017

Language:

english

File:

PDF, 1.02 MB

english, 2017

4

Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120

Curreli, Francesca, Belov, Dmitry S., Kwon, Young Do, Ramesh, Ranjith, Furimsky, Anna M., O'Loughlin, Kathleen, Byrge, Patricia C., Iyer, Lalitha V., Mirsalis, Jon C., Kurkin, Alexander V., Altieri, A

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 3.66 MB

english, 2018

5

Vaccination with a recombinant vaccinia vaccine containing the B7-1 co-stimulatory molecule causes no significant toxicity and enhances T cell–mediated cytotoxicity

Yvonne R. Freund, Jon C. Mirsalis, David G. Fairchild, Joyce Brune, Leslie A. Hokama, Janice Schindler-Horvat, Joseph E. Tomaszewski, James W. Hodge, Jeffrey Schlom, Judy A. Kantor, Charles A. Tyson,

Journal:

International Journal of Cancer

Year:

2000

Language:

english

File:

PDF, 154 KB

english, 2000

6

Chromium (VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver unscheduled DNA synthesis assays

Jon C. Mirsalis, Carol M. Hamilton, Kathleen G. O'Loughlin, Dennis J. Paustenbach, Brent D. Kerger, Steven Patierno

Journal:

Environmental and Molecular Mutagenesis

Year:

1996

Language:

english

File:

PDF, 325 KB

english, 1996

7

Mutational specificity: Spectrum of mutations in kidney, stomach, and liver from lacl transgenic mice recovered after treatment with tris(2,3-dibromopropyl)phosphate

Johan G. de Boer, Jon C. Mirsalis, G. Scott Provost, Kenneth R. Tindall, Barry W. Glickman

Journal:

Environmental and Molecular Mutagenesis

Year:

1996

Language:

english

File:

PDF, 579 KB

english, 1996

8

Prospects for safety testing: A strategy for the application of transgenic rodent mutagenesis assays

Nancy J. Gorelick, Jon C. Mirsalis

Journal:

Environmental and Molecular Mutagenesis

Year:

1996

Language:

english

File:

PDF, 999 KB

english, 1996

9

Evaluation of positive controls for the in vitro unscheduled DNA synthesis assay using hepatocytes from induced (Aroclor 1254) and uninduced male cynomolgus monkey

Carol M. Hamilton, Jack E. Dabbs, Glenn D. Cunningham, Lawrence A. Vernetti, Jon C. Mirsalis, Ronald D. Snyder

Journal:

Environmental and Molecular Mutagenesis

Year:

1997

Language:

english

File:

PDF, 47 KB

english, 1997

10

Mutational spectrum of dimethylnitrosamine in the liver of 3- and 6-week-old lacI transgenic mice

Johan G. de Boer, Jon C. Mirsalis, Barry W. Glickman

Journal:

Environmental and Molecular Mutagenesis

Year:

1999

Language:

english

File:

PDF, 49 KB

english, 1999

11

In vivo transgenic mutation assays

John A. Heddle, Stephen Dean, Takehiko Nohmi, Michaël Boerrigter, Daniel Casciano, George R. Douglas, Barry W. Glickman, Nancy J. Gorelick, Jon C. Mirsalis, Hans-Jörg Martus, Thomas R. Skopek, Veroniq

Journal:

Environmental and Molecular Mutagenesis

Year:

2000

Language:

english

File:

PDF, 71 KB

english, 2000

12

Evaluation of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) following treatment of rats and mice with p-dichlorobenzene

James H. Sherman, Rashmi S. Nair, Karen L. Steinmetz, Jon C. Mirsalis, Earle R. Nestmann, James A. Barter

Journal:

Teratogenesis, Carcinogenesis, and Mutagenesis

Year:

1998

Language:

english

File:

PDF, 49 KB

english, 1998

13

Micronucleated erythrocyte frequency in peripheral blood of B6C3F1 mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program

Kristine L. Witt, Alan Knapton, Carol M. Wehr, Graham J. Hook, Jon Mirsalis, Michael D. Shelby, James T. MacGregor

Journal:

Environmental and Molecular Mutagenesis

Year:

2000

Language:

english

File:

PDF, 138 KB

english, 2000

14

Pyridine does not induce unscheduled DNA synthesis (UDS) in hepatocytes of male B6C3F1 mice treated in vivo

Judith A. Macgregor, Carol M. Hamilton, James E. Kubicek, Jon C. Mirsalis

Journal:

Journal of Applied Toxicology

Year:

2000

Language:

english

File:

PDF, 54 KB

english, 2000

15

Nonprofit organizations and pharmaceutical research and development

Walter H. Moos, Jon C. Mirsalis

Journal:

Drug Development Research

Year:

2009

Language:

english

File:

PDF, 585 KB

english, 2009

16

Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E

Polly Y. Chang, Jon Mirsalis, Edward S. Riccio, James P. Bakke, Pamela S. Lee, Julie Shimon, Sandra Phillips, David Fairchild, Yukihiko Hara, James A. Crowell

Journal:

Environmental and Molecular Mutagenesis

Year:

2003

Language:

english

File:

PDF, 249 KB

english, 2003

17

Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13

Edward S. Riccio, Pamela S. Lee, Richard A. Winegar, Donald J. Krogstad, Dibyendu De, Jon C. Mirsalis

Journal:

Environmental and Molecular Mutagenesis

Year:

2001

Language:

english

File:

PDF, 116 KB

english, 2001

18

Evaluation of mutant frequencies of chemically induced tumors and normal tissues in λ/cII transgenic mice

Jon C. Mirsalis, Julie A. Shimon, Alphonso Johnson, David Fairchild, Nathan Kanazawa, Tung Nguyen, Johan de Boer, Barry Glickman, Richard A. Winegar

Journal:

Environmental and Molecular Mutagenesis

Year:

2005

Language:

english

File:

PDF, 187 KB

english, 2005

19

Measurement of unscheduled DNA synthesis and S-phase synthesis in rodent hepatocytes following in vivo treatment: Testing of 24 compounds

Jon C. Mirsalis, C. Kim Tyson, Karen L. Steinmetz, Erica K. Loh, Carol M. Hamilton, James P. Bakke, Judson W. Spalding

Journal:

Environmental and Molecular Mutagenesis

Year:

1989

Language:

english

File:

PDF, 665 KB

english, 1989

20

Evaluation of the potential of riddelliine to induce unscheduled DNA synthesis, S-phase synthesis, or micronuclei following in vivo treatment with multiple doses

Dr. Jon C. Mirsalis, Karen L. Steinmetz, Dr. William F. Blazak, Judson W. Spalding

Journal:

Environmental and Molecular Mutagenesis

Year:

1993

Language:

english

File:

PDF, 653 KB

english, 1993

21

Letter to the editor

Journal:

Environmental and Molecular Mutagenesis

Year:

1993

Language:

english

File:

PDF, 70 KB

english, 1993

22

Detection of genotoxic carcinogens in the in vivo-in vitro hepatocyte dna repair assay

Dr. Jon C. Mirsalis, C. Kim Tyson, Byron E. Butterworth

Journal:

Environmental and Molecular Mutagenesis

Year:

1982

Language:

english

File:

PDF, 548 KB

english, 1982

23

Induction of unscheduled DNA synthesis in primary cultures of rat pancreatic cells following in vivo and in vitro treatment with genotoxic agents

Karen L. Steinmetz, Jon C. Mirsalis

Journal:

Environmental and Molecular Mutagenesis

Year:

1984

Language:

english

File:

PDF, 819 KB

english, 1984

24

Measurement of unscheduled DNA synthesis in rat kidney cells following in vivo treatment with genotoxic agents

C. Kimerly Tyson, Jon C. Mirsalis

Journal:

Environmental and Molecular Mutagenesis

Year:

1985

Language:

english

File:

PDF, 778 KB

english, 1985

25

Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs

John E. Coughlin, Seetharamaiyer Padmanabhan, Guangrong Zhang, Cassandra J. Kirk, Chandrika P. Govardhan, Brent E. Korba, Kathleen O’Loughlin, Carol E. Green, Jon Mirsalis, John D. Morrey, Radhakrishn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 483 KB

english, 2010

26

Professional Toxicology Societies: Web Based Resources

James P. Kehrer, Jon Mirsalis

Journal:

Year:

2001

Language:

english

File:

PDF, 78 KB

english, 2001

27

In Vivomeasurement of unscheduled DNA synthesis and S-phase synthesis as an indicator of hepatocarcinogenesis in rodents

Jon C. Mirsalis

Journal:

Cell Biology and Toxicology

Year:

1987

Language:

english

File:

PDF, 520 KB

english, 1987

28

Biodistribution, toxicity and radiation dosimetry studies of the serotonin transporter radioligand 4-[18F]-ADAM in rats and monkeys

Ya-Yao Huang, Kuo-Hsing Ma, Ta-Wei Tseng, Ta-Kai Chou, Hanna Ng, Jon C. Mirsalis, Ying-Kai Fu, Tieh-Chi Chu, Wen-Sheng Huang, Chyng-Yann Shiue

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2010

Language:

english

File:

PDF, 265 KB

english, 2010

29

Toxicity of a quinocarmycin analog, DX-52-1, in rats and dogs in relation to clinical outcome

Jon C. Mirsalis, Janice Schindler-Horvat, James R. Hill, Carol E. Green, Chozo Mitoma, Joseph E. Tomaszewski, Charles A. Tyson, Susan J. Donohue

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2003

Language:

english

File:

PDF, 308 KB

english, 2003

30

Preclinical pharmacokinetic, toxicological and biomarker evaluation of SR16157, a novel dual-acting steroid sulfatase inhibitor and selective estrogen receptor modulator

Linda Rausch, Carol Green, Karen Steinmetz, Sue LeValley, Paul Catz, Nurulain Zaveri, Karen Schweikart, Joseph Tomaszewski, Jon Mirsalis

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 468 KB

english, 2011

31

Preclinical Acute Toxicity Studies and Dosimetry Estimates of the Novel Sigma-1 Receptor Radiotracer, [18F]SFE

Rikki N. Waterhouse, Jun Zhao, Michael G. Stabin, Hanna Ng, Janice Schindler-Horvat, Raymond C. Chang, Jon C. Mirsalis

Journal:

Molecular Imaging and Biology

Year:

2006

Language:

english

File:

PDF, 278 KB

english, 2006

32

Role of gut flora in the genotoxicity of dinitrotoluene

Mirsalis, Jon C., Hamm, Thomas E., Sherrill, J. Michael, Butterworth, Byron E.

Journal:

Year:

1982

File:

PDF, 266 KB

1982

33

Induction of hepatic mutations in lacI transgenic mice

Mirsalis, Jon C., Provost, G.Scott, Matthews, Crystal D., Hamner, Richard T., Schindler, Janice E., O'Loughlin, Kathleen G., MacGregor, James T., Short, Jay M.

Journal:

Year:

1993

Language:

english

File:

PDF, 595 KB

english, 1993

34

Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice

Richard A. Winegar, Louise H. Lutze, Janice D. Hamer, Kathleen G. O'Loughlin, Jon C. Mirsalis

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1994

Language:

english

File:

PDF, 682 KB

english, 1994

35

Synthesis and Tissue Distribution Studies of Acyloxyalkyl Prodrug Derivative of an Anti-HBV Dinucleotide

John Coughlin, Kathleen O’Loughlin, Sung Rhee, Mary Tanga, Radhakrishnan Iyer, Anna Furimsky, Seetharamaiyer Padmanabhan, Judith Marquis, Amy Ta, Carol Green, Jon Mirsalis

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 80 KB

english, 2010

36

Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs

Radhakrishnan Iyer, John Coughlin, Cassandra Kirk, Seetharamaiyer Padmanabhan, Brent Korba, Kathleen O’Loughlin, Carol Green, Jon Mirsalis, John Morrey

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 67 KB

english, 2010

37

O XV A.2 - O XV A.2 A proposal for the use of in vivo mutation assays In cancer assessments

Nancy J. Gorelick, Jon C. Mirsalis

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1997

Language:

english

File:

PDF, 120 KB

english, 1997

38

Detection of unscheduled DNA synthesis in hepatocytes isolated from rats treated with genotoxic agents: an in vivo â in vitro assay for potential carcinogens and mutagens

Mirsalis, Jon C., Butterworth, Byron E.

Journal:

Year:

1980

Language:

english

File:

PDF, 378 KB

english, 1980

39

Transgenic Animals in Toxicology

Thomas L. Goldsworthy, Leslie Recio, Ken Brown, Lawrence A. Donehower, Jon C. Mirsalis, Raymond W. Tennant, Iain F.H. Purchase

Journal:

Fundamental and Applied Toxicology

Year:

1994

File:

PDF, 752 KB

1994

40

4 CCL2/Monocyte-Chemoattractant Protein-1 as a Novel Biomarker for the Safety Evaluation of Microbicide-induced Vaginal Irritation

Carsten Alt, Travis Harrison, Nahoko Fujita, Kenneth Shew, Thuy Tran, Akihiro Matsukawa, Charles Litterst, Jon Mirsalis, Annalisa D’Andrea

Journal:

Year:

2007

Language:

english

File:

PDF, 79 KB

english, 2007

41

Gene expression profiling of mouse host response to Listeria monocytogenes infection

Hanna H. Ng, Christopher E. Frantz, Linda Rausch, David C. Fairchild, Julie Shimon, Edward Riccio, Sherrod Smith, Jon C. Mirsalis

Journal:

Year:

2005

Language:

english

File:

PDF, 402 KB

english, 2005

42

Analysis of the mutagenic potential of ENU and MMS in germ cells of male C57BL/6 lacI transgenic mice

Richard A Winegar, Greg Carr, Jon C Mirsalis

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

1997

Language:

english

File:

PDF, 123 KB

english, 1997

43

Transgenic models for detection of mutations in tumors and normal tissues of rodents

Jon C. Mirsalis

Journal:

Toxicology Letters

Year:

1995

Language:

english

File:

PDF, 406 KB

english, 1995

44

A protocol and guide for the in vivo rat hepatocyte DNA-repair assay

Byron E. Butterworth, John Ashby, Edilberto Bermudez, Daniel Casciano, Jon Mirsalis, Gregory Probst, Gary Williams

Journal:

Mutation Research/Genetic Toxicology

Year:

1987

Language:

english

File:

PDF, 879 KB

english, 1987

45

A protocol and guide for the in vitro rat hepatocyte DNA-repair assay

Byron E. Butterworth, John Ashby, Edilberto Bermudez, Daniel Casciano, Jon Mirsalis, Gregory Probst, Gary Williams

Journal:

Mutation Research/Genetic Toxicology

Year:

1987

Language:

english

File:

PDF, 763 KB

english, 1987

46

Factors that affect the sensitivity of the in vivo-in vitro hepatocyte DNA repair assay in the male rat

Carol M. Hamilton, Jon C. Mirsalis

Journal:

Mutation Research/Genetic Toxicology

Year:

1987

Language:

english

File:

PDF, 548 KB

english, 1987

47

Induction of unscheduled DNA synthesis in primary cultures of rat, mouse, hamster, monkey, and human hepatocytes

Karen L. Steinmetz, Carol E. Green, James P. Bakke, Dana K. Spak, Jon C. Mirsalis

Journal:

Mutation Research/Genetic Toxicology

Year:

1988

Language:

english

File:

PDF, 828 KB

english, 1988

48

Serum Biomarkers Reveal Long-term Cardiac Injury in Isoproterenol-treated African Green Monkeys

Liu, Yashu, Parman, Toufan, Schneider, Bridget, Song, Benben, Galande, Amit K., Anderson, Dave, Mirsalis, Jon

Journal:

Journal of Proteome Research

Year:

2013

Language:

english

File:

PDF, 3.12 MB

english, 2013

49

Pharmacokinetics and dose-range finding toxicity of a novel anti-HIV active integrase inhibitor

Nair, Vasu, Okello, Maurice, Mishra, Sanjay, Mirsalis, Jon, O’Loughlin, Kathleen, Zhong, Yu

Journal:

Antiviral Research

Year:

2014

Language:

english

File:

PDF, 680 KB

english, 2014

50

Transgenic Animals in Toxicology

GOLDSWORTHY, THOMAS L., REICO, LESLIE, BROWN, KEN, DONEHOWER, LAWRENCE A., MIRSALIS, JON C., TENNANT, RAYMOND W., PURCHASE, IN

Journal:

Toxicological Sciences

Year:

1994

Language:

english

File:

PDF, 4.47 MB

english, 1994